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The chitosan nanoparticle group exhibited superior therapeutic effects, likely due to the electrostatic interactions between chitosan and the skin surface, which resulted in prolonged local skin retention of the nanoparticles.Enhancing the skin affinity of polymer nanoparticles through surface modification is another effective approach to improve their skin drug delivery capabilities

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FIGURE 1 2.1 Iron metabolism imbalance Iron, an essential trace element, primarily participates in metabolic processes in the forms of Fe 2+ and Fe 3+ (Lee and Roh, 2025)